Cover of Immunity for December, 2017
Embryonic development requires the formation of a special maternal-fetal interface to protect the normal development of the fetus. In the first trimester of gestation, 70% of the total lymphocytes of this interface are dNKs. Through genome-wide screening, researchers found that compared with peripheral blood NK cells, early pregnancy dNK cells highly express PTN and OGN, which are vital growth factors for early embryo development. Moreover, the trigger of their massive growth facto expression lies in the crosstalk with HLA-G from embryonic extra-trophoblast cells.
dNK cells promote embryonic growth by secreting growth factors early in gestation
Do dNK cells play a part in common clinical pregnancy-related disease such as limited embryonic development and recurrent abortion? Yes, at least in two ways.
On one hand, the ability to express growth factors of dNK cells is significantly reduced in repeated abortion patients, thus they can no longer support the normal development of early embryos. The deletion of the transcription factor Nfil3 in mouse leads to substantial reduction of NK cells in maternal-fetal interface, indicating important role of Nfil3 in ensuring proper function of CD49a+Eomes+ NK cell subsets. On the other hand, the incidence of abortion and embryo growth restriction was even higher in advanced pregnancy. Researchers found that the capacity of secreting growth factors of dNK cells in older mice was significantly decreased, though the population remains quite still.
Facing the challenge, researchers explored an adoptive transfer strategy of specific NK cell subsets for the treatment of embryonic growth restriction and recurrent miscarriage and other related diseases.
The group induced the decidual-like NK cells with bone marrow hematopoietic stem cells in vitro, then adoptively transfered the cells to mice by intravenous infusion. To our excitement, both the aged mice and growth factor deficient mice showed significant improvement in pregnancy outcomes as well as embryo growth, clarifying dNK cells in the decidua as a unique promoter for the physiological function of embryonic development.
The finding is expected to arouse widespread attention in reproductive immunity and has been published in Immunity on December 19st, 2017. The research is funded by the National Natural Science Foundation.
(GUO Jianjian, USTC News Center)
According to the latest Nature Publishing Index (NPI) Asia-Pacific and The Nature Publishing Index China, University of Science and Technology of China tops in Chinese universities again. The rankings are based on the number of papers that were published in Nature journals during the last 12 months.
This article came from News Center of USTC.