Researchers discovered a lncRNA called lncRNA-Assisted Stabilization of Transcripts (LAST) activated by c-Myc transcription, which can stabilize CCND1 mRNA, therefore leading to an increasing in the amount of Cyclin D1 protein and promoting more rapid cell cycle operation and tumorigenesis. The work was done by research team led by Professor WU Mian from University of Science and Technology of China (USTC) and published in the world-renowned eLife journal, titled as “LAST, a c-Myc-Inducible long noncoding RNA, cooperates with CNBP to promote CCND1 mRNA stability in human cells”.
The research reports the isolation and characterization of the novel c-Myc-regulated LAST, which acts as a CCND1 mRNA stabilizer. LAST can guide the RNA binding protein CNBP to co-bind with 5’UTR of CCND1 mRNA to In addition, the study also found that LAST/CNBP could regulate the stability of a series of other mRNA through a similar mechanism. This study, for the first time, elucidats the mechanism by which lncRNA regulates the stability of CCND1 mRNA and proves that LAST is a non-coding RNA promoting cancer, which provides a potential target for the diagnosis and treatment of related cancers.
A schematic illustration of the proposed model depicting the role of c-Myc-induced LAST in regulating CCND1 mRNA stability via CNBP (Image by WU)
Professor WU Mian from USTC is the corresponding author. CAO Limian and ZHANG Pengfei, doctoral students from the research group are the co-authors of this paper. The research was supported by grants from the National Key R&D Program of China and National Natural Science Foundation of China.
The link of the paper: https://www.ncbi.nlm.nih.gov/pubmed/29199958
Professor WU Mian
(DENG Weiting, USTC News Center)
On May 11, the Nature Publishing Group released Nature Publishing Index 2010 China, remarking “a dramatic rise in the quality of research being published by China”. University of Science and Technology of China is ranked 3rd of TOP 10 Institutions in Index 2010 China.
This article came from News Center of USTC.